An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
نویسندگان
چکیده
منابع مشابه
Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1
Caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1β (IL-1β) secretion by potentiating caspase-1 activation and induces caspase-1-independent pyroptosis downstream of noncanonical NLRP3 inflammasome activators such as lipopolysaccharide (LPS) and Gram-negative bacteria. However, we still know very little about the ...
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ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aaf3036